Tri-Luma Cream is a medicine that consists of Tretinoin, Hydroquinone, and Fluocinolone. It is used for the short-term treatment of moderate-to-severe melasma (a condition where dark, discoloured patches appear on the skin) of the face. This medicine acts by brightening the skin and decreasing the action of chemicals that cause dark patches, swelling, and irritation of the skin.